Depression is one of the most common and undiagnosed mental illnesses in the world, affecting 264 million people around the globe. In the United States alone, one study showed adults aged 18 or older experienced at least one major depressive episode within the last year. Symptoms of depression can range in severity and may include an ongoing feeling of sadness, loss of interest, and other negative changes in behavior and mood. While there are treatments available for depression, like talk therapy, lifestyle changes, and prescription-based therapy, there is currently no cure for the disorder. Seeking relief, some patients have reported positive results using weed for depression. Weed strains that may help with depression tend to be sativa-dominant.